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Full education sheets & dosing protocols available in the Members Area
Retatrutide is a next-generation triple agonist — the first compound to simultaneously activate GLP-1, GLP-2, and GIP receptors. GLP-1 activation suppresses appetite and improves insulin secretion. GIP activation enhances GLP-1's effects and directly promotes fat cell breakdown. GLP-2 activation improves gut integrity and nutrient efficiency. Clinical research demonstrates average body weight reductions of 17–24% over 48 weeks.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
5-Amino-1MQ is a small molecule inhibitor of Nicotinamide N-methyltransferase (NNMT) — an enzyme that, when overactive, suppresses your body's ability to burn fat. By blocking NNMT, this compound raises intracellular NAD+ levels and activates the SIRT1 pathway, essentially switching on your body's fat-burning machinery. The result is enhanced lipolysis and improved metabolic efficiency without the hormonal disruption of stimulant-based approaches.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
AOD9604 is a modified fragment of human growth hormone (hGH), specifically the C-terminal region (amino acids 176–191). This fragment retains hGH's fat-burning properties while eliminating the growth-promoting and insulin-disrupting effects of full HGH. It activates beta-3 adrenergic receptors to stimulate lipolysis and simultaneously inhibits the enzymes responsible for creating new fat cells — all without affecting blood glucose or IGF-1 levels.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
Cagrilintide is a long-acting amylin analogue. Amylin is a hormone naturally co-secreted with insulin by the pancreas after eating, but is often deficient in overweight individuals. By mimicking and amplifying amylin's effects, Cagrilintide sends powerful satiety signals to the hypothalamus, slows gastric emptying, and reduces post-meal glucose spikes. When combined with a GLP-1 receptor agonist, appetite suppression is significantly amplified through complementary pathways.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
CJC-1295 without DAC is a synthetic analogue of Growth Hormone Releasing Hormone (GHRH). It binds to GHRH receptors on the pituitary gland, stimulating a natural, pulsatile release of growth hormone. Without the DAC ester, its ~30 minute half-life produces GH pulses that closely mimic the body's natural rhythms — ideal for pairing with GHRPs like Ipamorelin, which amplify the GH pulse through a complementary receptor pathway.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
L-Carnitine is a naturally occurring amino acid derivative essential to energy metabolism. It acts as a shuttle — transporting long-chain fatty acids across the inner mitochondrial membrane to be oxidized for energy. Without adequate carnitine, fat cannot enter the mitochondria efficiently and is stored instead. Injectable L-Carnitine bypasses oral absorption limitations, delivering dramatically higher plasma concentrations for maximum fat transport at the cellular level.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
MOTS-c is a mitochondria-derived peptide encoded in the mitochondrial genome — one of the few peptides produced by mitochondria rather than nuclear DNA. It functions as a powerful AMPK activator, triggering the same cellular energy-sensing cascade activated by intense aerobic exercise. This translates to improved glucose uptake, enhanced fat oxidation, reduced visceral fat, and dramatically improved insulin sensitivity — all without physical exertion. MOTS-c levels naturally decline with age, making supplementation especially valuable for clients over 40.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
Tesamorelin is a synthetic analogue of Growth Hormone Releasing Hormone (GHRH) with an added trans-3-hexenoic acid group that extends its stability and half-life. It binds to GHRH receptors on the pituitary gland, stimulating natural growth hormone production. Elevated GH then promotes lipolysis — particularly visceral fat — while simultaneously supporting lean muscle development and collagen synthesis. Its FDA study history gives it one of the strongest evidence bases for visceral fat reduction of any compound in this category.
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AICAR (5-Aminoimidazole-4-carboxamide ribonucleoside) is an adenosine analogue that activates AMP-activated protein kinase (AMPK) — the same cellular pathway activated by intense endurance exercise. By mimicking this signal, AICAR triggers glucose uptake, fatty acid oxidation, and mitochondrial biogenesis without physical exertion. It also has significant anti-inflammatory effects and has been studied for its role in improving metabolic health, endurance capacity, and cellular resilience.
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ARA 290 (also known as Cibinetide) is a peptide derived from the non-hematopoietic region of erythropoietin (EPO). It activates the Innate Repair Receptor (IRR) — a tissue-protective receptor expressed throughout the body — triggering powerful anti-inflammatory and regenerative responses. Unlike full EPO, it carries no risk of erythrocytosis or cardiovascular side effects. It has been studied extensively for neuropathic pain, small fiber neuropathy, metabolic repair, and ischemic tissue healing.
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BPC 157 (Body Protection Compound 157) is a synthetic pentadecapeptide derived from a protective protein found in human gastric juice. It works through multiple repair mechanisms: upregulating growth hormone receptors, stimulating angiogenesis via VEGF pathways, reducing inflammatory cytokines, and activating healing cascades in tendons, muscles, ligaments, and the gut lining. It has shown remarkable regenerative effects across nearly every tissue type studied — earning it the nickname "the wolverine compound" among researchers.
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FOXO4-DRI is a D-amino acid retro-inverso peptide that disrupts the survival mechanism of senescent cells — cells that have stopped dividing but refuse to die, releasing inflammatory signals that damage surrounding tissue. Normally, senescent cells are protected from apoptosis by FOXO4 binding to p53. FOXO4-DRI competitively displaces this interaction, triggering selective apoptosis in senescent cells while leaving healthy cells completely unharmed. The result is clearance of cellular debris, reduction of chronic inflammation, and restoration of tissue regenerative capacity.
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Glutathione is the body's most powerful endogenous antioxidant, produced in every cell. It neutralizes reactive oxygen species (free radicals), recycles other antioxidants like vitamins C and E, supports the liver's Phase II detoxification pathways, and plays a central role in immune function. Levels naturally decline with age, stress, illness, and toxic exposure. Injectable glutathione bypasses the poor oral bioavailability of the supplement form, delivering therapeutic concentrations directly into circulation for maximum systemic benefit.
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KPV is a tripeptide (Lysine-Proline-Valine) derived from the C-terminal of alpha-melanocyte stimulating hormone (α-MSH). It exerts powerful anti-inflammatory effects by directly inhibiting NF-κB signaling — a master regulator of inflammation. It also activates melanocortin receptors in the gut, making it particularly effective for intestinal inflammation and repair. Its small size allows excellent tissue penetration, and it has shown significant wound healing and antimicrobial properties in addition to its anti-inflammatory effects.
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NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell, essential for energy metabolism, DNA repair, and cellular signaling. Levels decline significantly with age — dropping by approximately 50% between ages 40 and 60. Injectable NAD+ delivers therapeutic concentrations directly into the bloodstream, activating sirtuins (longevity proteins), supporting mitochondrial health, enhancing DNA repair mechanisms, and restoring the cellular energy currency that powers every biological process in the body.
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SS-31 (also known as Elamipretide) is a mitochondria-targeted antioxidant peptide that selectively concentrates in the inner mitochondrial membrane — the site of ATP production and the primary source of reactive oxygen species (ROS). By binding to cardiolipin, a phospholipid critical to mitochondrial membrane function, SS-31 reduces electron leakage, improves electron transport chain efficiency, and dramatically reduces mitochondrial ROS production. The result is improved cellular energy output, reduced oxidative damage, and protection of organs — especially the heart — from ischemic and age-related decline.
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TB-500 is a synthetic version of Thymosin Beta-4, a naturally occurring peptide found in high concentrations at injury sites. It works by upregulating actin — a protein essential for cell migration, proliferation, and repair. This allows healing cells to migrate rapidly to injury sites, promoting faster tissue repair. TB-500 also stimulates angiogenesis (new blood vessel growth), reduces inflammation, and minimizes scar tissue formation. Unlike many healing peptides that act locally, TB-500 distributes systemically, allowing it to address multiple injury sites simultaneously.
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VIP (Vasoactive Intestinal Peptide) is a 28-amino acid neuropeptide found throughout the nervous system, gut, and lungs. It exerts powerful anti-inflammatory effects by suppressing pro-inflammatory cytokines (TNF-α, IL-6, IL-12) while stimulating anti-inflammatory mediators. It also acts as a potent vasodilator, improving blood flow and tissue perfusion, supports gut motility, protects pulmonary tissue, and has neuroprotective effects by reducing neuroinflammation. VIP has been studied for chronic inflammatory conditions, CIRS (Chronic Inflammatory Response Syndrome), and post-viral recovery.
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FST-344 (Follistatin 344) is a naturally occurring protein that acts as a potent inhibitor of myostatin — the protein that limits muscle growth. By binding to and neutralizing myostatin, FST-344 removes the ceiling on muscle development, allowing for muscle growth beyond genetic limitations. It also binds activin, another growth inhibitor, and has been shown to significantly improve lean muscle mass, strength, and body composition. When combined with GH-stimulating peptides, the anabolic effect is dramatically amplified.
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GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide that strongly stimulates GH secretion by activating the ghrelin receptor (GHS-R1a) on the pituitary. It produces one of the strongest GH pulses of any GHRP, second only to Hexarelin. GHRP-2 also stimulates appetite through its ghrelin-mimetic mechanism, making it valuable for clients needing to increase caloric intake. When paired with a GHRH like CJC-1295, the GH pulse is synergistically amplified beyond what either compound achieves alone.
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GHRP-6 (Growth Hormone Releasing Peptide-6) is a hexapeptide GH secretagogue that stimulates GH release through ghrelin receptor activation. It produces a strong GH pulse and is particularly well known for its powerful appetite-stimulating effect — making it one of the best choices for clients who need to increase food intake alongside GH benefits. GHRP-6 also has gastroprotective properties and has been studied for its ability to protect and heal the gastrointestinal lining, working synergistically with BPC-157 in gut repair protocols.
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Hexarelin is the most potent GHRP available, producing the strongest GH pulse of any peptide in this class. It activates both the ghrelin receptor and a separate cardiac receptor (CD36), giving it unique cardioprotective properties not seen in other GHRPs. Studies have shown Hexarelin can protect heart muscle from ischemic damage, reduce cardiac fibrosis, and improve heart function following injury. Its anabolic and fat-loss effects from GH stimulation are substantial. Due to its potency, it desensitizes faster than other GHRPs and is typically cycled.
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HGH 191AA is synthetic human growth hormone with the complete 191 amino acid sequence identical to endogenous pituitary GH. It works through GH receptors throughout the body to stimulate IGF-1 production, promote protein synthesis, increase lipolysis, support bone metabolism, and enhance cellular regeneration. As the most direct form of growth hormone supplementation, it produces the full spectrum of GH effects — anabolic, lipolytic, anti-aging, and regenerative — at a level unmatched by secretagogues alone.
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HGH Fragment 176-191 is a stabilized analogue of the C-terminal fragment of human growth hormone, specifically the region responsible for hGH's fat-metabolizing effects. By isolating this fragment, the fat-burning properties of GH are retained while entirely eliminating the growth-promoting, blood sugar-disrupting, and IGF-1-stimulating effects of full HGH. It activates beta-3 adrenergic receptors to directly stimulate lipolysis and inhibit lipogenesis — targeting stored fat for fuel without any of the metabolic risks associated with full growth hormone use.
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IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) is a recombinant analogue of IGF-1 with a modified sequence that extends its half-life from minutes to approximately 20–30 hours. IGF-1 is the primary downstream mediator of GH's anabolic effects — it directly stimulates muscle cell proliferation, protein synthesis, nitrogen retention, and fat oxidation. The LR3 modification also reduces IGF binding protein affinity, meaning more free IGF-1 is available to act on receptors. The result is a significantly more potent and longer-acting anabolic signal than standard IGF-1.
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Ipamorelin is a selective pentapeptide GHRP that stimulates GH release through the ghrelin receptor with exceptional selectivity — meaning it produces a clean GH pulse with minimal impact on cortisol, prolactin, or appetite. This makes it the most versatile and well-tolerated GHRP available. When combined with CJC-1295 without DAC, the combination creates a synergistic GH pulse that closely mimics the body's natural growth hormone rhythm — maximizing anabolic and lipolytic effects while maintaining a favorable hormonal environment.
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MGF (Mechano Growth Factor) is an isoform of IGF-1 produced locally in muscle tissue in response to mechanical stress (exercise or damage). It activates muscle satellite cells — stem cells that initiate muscle repair and growth. MGF is unique in that it acts locally at the site of muscle stress rather than systemically, and it acts in the immediate post-exercise window before converting to standard IGF-1. This makes it ideal for injection directly into or near recently trained muscle groups for localized growth stimulus. It has a very short half-life and should be used immediately after training.
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PEG-MGF is a PEGylated form of Mechano Growth Factor — standard MGF with a polyethylene glycol molecule attached that dramatically extends its half-life from minutes to several days. This modification transforms MGF from a locally-acting, timing-critical peptide into a systemically-acting compound that can be dosed less frequently while still activating muscle satellite cells throughout the body. PEG-MGF is ideal for clients who want the muscle repair and growth benefits of MGF without the strict post-workout injection timing requirement.
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Sermorelin Acetate is a synthetic analogue of the first 29 amino acids of natural GHRH (growth hormone releasing hormone) — the minimum sequence required for full biological activity. It binds to GHRH receptors on the pituitary gland to stimulate natural, pulsatile GH production. Sermorelin has one of the longest clinical track records of any GH secretagogue, having been FDA-studied and used in clinical settings for decades. It produces a more physiological GH release pattern than exogenous HGH, reducing the risk of pituitary suppression or IGF-1 overstimulation.
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Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from Epithalamin — a natural extract of the pineal gland. Its primary mechanism involves activation of telomerase, the enzyme responsible for maintaining telomere length. Telomeres shorten with each cell division and are a primary driver of cellular aging. By restoring telomerase activity, Epithalon allows cells to divide more times before reaching their Hayflick limit, effectively slowing the biological aging process. It also regulates the pineal gland's production of melatonin, improving sleep architecture and circadian function.
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Orexin A (Hypocretin-1) is a neuropeptide produced in the hypothalamus that plays a central role in regulating wakefulness, arousal, appetite, and energy homeostasis. It acts on OX1R and OX2R receptors throughout the brain and body to promote sustained alertness and cognitive clarity. Unlike stimulants, Orexin A works through the brain's natural arousal system rather than forcing adrenergic release, making its wakefulness-promoting effects smoother and more physiological. It is deficient in narcolepsy and has been studied extensively for sleep disorders and cognitive enhancement.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
Orexin B (Hypocretin-2) is the second orexin neuropeptide, structurally similar to Orexin A but with preferential affinity for the OX2R receptor over OX1R. OX2R is more densely expressed in brain regions specifically associated with sleep/wake switching, making Orexin B particularly relevant for circadian rhythm regulation and wakefulness maintenance. While Orexin A has broader arousal and appetite effects, Orexin B's receptor selectivity makes it a valuable tool for targeted sleep/wake and metabolic regulation when used alongside or alternating with Orexin A.
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P21 is a truncated analogue of CNTF (Ciliary Neurotrophic Factor) designed to cross the blood-brain barrier and stimulate BDNF production — the primary driver of neurogenesis and synaptic plasticity. BDNF promotes survival of existing neurons, encourages growth of new neurons in the hippocampus, supports long-term potentiation (the cellular basis of memory), and protects against neurodegeneration. P21 also reduces amyloid precursor protein processing, making it one of the most promising neuroprotective peptides studied in relation to Alzheimer's disease prevention.
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PE-22-28 is a synthetic peptide derived from spadin, a natural sortilin-derived peptide. It acts as a TREK-1 channel antagonist — blocking a potassium channel that, when overactive, suppresses serotonin release and neural excitability. By inhibiting TREK-1, PE-22-28 increases serotonergic neurotransmission and BDNF expression, producing rapid antidepressant and anxiolytic effects. Its mechanism is entirely distinct from SSRIs, making it compatible with existing treatments and carrying no serotonin syndrome risk. Onset of effects is significantly faster than conventional antidepressants.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
Selank is a synthetic heptapeptide analogue of the human tetrapeptide tuftsin, developed by the Institute of Molecular Genetics in Russia. It exerts anxiolytic effects by modulating GABAergic, serotonergic, and dopaminergic neurotransmission — reducing anxiety without the sedation, cognitive impairment, or dependency risk of benzodiazepines. It also upregulates BDNF and NGF (nerve growth factor), supporting neuroplasticity and neuroprotection. Its immune-modulating effects — reducing pro-inflammatory cytokines while supporting T-cell function — make it uniquely valuable for clients with stress-related immune dysregulation.
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Semax is a synthetic heptapeptide derived from the ACTH(4-7) fragment — the sequence responsible for ACTH's cognitive effects without its hormonal activity. It was originally developed by the Institute of Molecular Genetics in Moscow and has been in clinical use in Russia for stroke recovery and cognitive enhancement for decades. Semax dramatically upregulates BDNF and NGF expression, supports serotonergic and dopaminergic neurotransmission, improves cerebral blood flow, and protects neurons from ischemic and oxidative damage. It is one of the most well-studied cognitive enhancement peptides available.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide first isolated from rabbit cerebral venous blood during slow-wave sleep. It exerts sleep-promoting effects by modulating central nervous system activity, reducing corticotropin release (lowering cortisol), and influencing the hypothalamic-pituitary axis to promote relaxation and sleep onset. Unlike pharmaceutical sleep aids, DSIP works through the body's natural sleep regulation pathways — improving sleep quality and architecture without causing sedation, grogginess, or dependency.
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Pinealon is a synthetic tripeptide (Glu-Asp-Arg) that acts as a bioregulator of the pineal gland — the brain's master clock and melatonin production center. As the pineal gland ages, its function declines, disrupting melatonin cycles, circadian rhythm, and downstream hormonal regulation. Pinealon restores and protects pineal gland cells, normalizing melatonin production and improving the sleep/wake cycle. It also has direct neuroprotective effects, reducing oxidative stress in brain tissue and supporting cognitive function through improved circadian regulation.
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LL-37 is the only known human cathelicidin — a naturally occurring antimicrobial peptide produced by immune cells, epithelial cells, and skin. It functions as a key component of innate immunity: directly killing pathogens by disrupting their cell membranes, modulating the inflammatory response to prevent both under- and over-reaction, promoting chemotaxis of immune cells to infection sites, and accelerating wound healing. It also disrupts bacterial biofilms — the protective matrices that allow chronic infections to persist — making it uniquely effective for antibiotic-resistant or recurrent infections.
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Thymalin is a natural peptide extract derived from the thymus gland, containing a complex mixture of biologically active peptides that regulate T-cell development and immune function. The thymus gland — which produces and matures T-cells — begins involuting (shrinking) after puberty and continues declining with age, leading to progressive immune deterioration. Thymalin restores thymic function, increases T-cell production and activity, and normalizes the cytokine environment, effectively reversing age-related immune decline and improving the body's ability to mount effective responses to pathogens and abnormal cells.
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Thymosin Alpha-1 (Tα1) is a 28-amino acid peptide originally isolated from thymosin fraction 5 — an extract from the thymus gland. It is one of the most extensively studied immunomodulatory peptides in existence, with clinical use in over 35 countries for viral hepatitis, cancer, and immunodeficiency. Tα1 works by activating dendritic cells and T-helper cells, increasing IL-2 and interferon-gamma production, enhancing NK (natural killer) cell activity, and promoting the maturation of cytotoxic T-lymphocytes. This comprehensive immune activation makes it effective against viral infections, tumor cells, and chronic inflammatory conditions.
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Kisspeptin-10 is a neuropeptide fragment of the kisspeptin family that acts on GPR54 receptors in the hypothalamus to stimulate GnRH (gonadotropin-releasing hormone) release. GnRH then triggers LH and FSH secretion from the pituitary, which drives testosterone production in men and estrogen/progesterone production in women. Kisspeptin is the upstream gatekeeper of the entire reproductive hormonal axis — making it a uniquely powerful tool for addressing libido, fertility, and hormonal balance at the root level rather than through exogenous hormone replacement.
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Oxytocin is the brain's primary bonding and attachment neuropeptide — released naturally during physical touch, orgasm, childbirth, and breastfeeding. It acts on oxytocin receptors throughout the brain and body to promote feelings of trust, emotional closeness, relaxation, and sexual arousal. Beyond its role in bonding, oxytocin has significant anxiolytic effects, reduces social stress reactivity, and has been studied for its anti-inflammatory properties through vagal nerve activation. It works synergistically with PT-141 for comprehensive sexual and emotional health optimization.
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PT-141 (Bremelanotide) is a synthetic melanocortin analogue that activates MC3R and MC4R receptors in the hypothalamus — the brain's sexual arousal center. Unlike PDE5 inhibitors (Viagra, Cialis) which work through vascular mechanisms, PT-141 works centrally to generate actual sexual desire and arousal. This makes it effective for both men and women, and for cases of low libido where there is no vascular component. It has been studied extensively and its analogue Bremelanotide received FDA approval for hypoactive sexual desire disorder in women.
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Gonadorelin Acetate is a synthetic version of GnRH (Gonadotropin-Releasing Hormone) — the hypothalamic hormone that signals the pituitary to release LH and FSH. When administered in pulses that mimic the natural hypothalamic rhythm, it maintains the entire HPG (hypothalamic-pituitary-gonadal) axis function during exogenous testosterone use. This prevents testicular atrophy, maintains fertility, and preserves natural LH/FSH signaling — addressing one of the most significant side effects of TRT. Gonadorelin has gained significant attention as an alternative to HCG following HCG availability challenges.
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HCG (Human Chorionic Gonadotropin) is a glycoprotein hormone that mimics LH (Luteinizing Hormone) — the pituitary signal that directly stimulates Leydig cells in the testes to produce testosterone. During exogenous testosterone use, LH production is suppressed, causing testicular atrophy and cessation of natural testosterone production. HCG bypasses the pituitary and directly stimulates the testes, maintaining their function, size, and intratesticular testosterone levels regardless of exogenous testosterone use. It is also used in post-cycle therapy (PCT) to restart natural testosterone production after a cycle.
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Triptorelin Acetate is a synthetic GnRH decapeptide analogue with significantly higher potency and longer duration than natural GnRH. When used in low, pulsatile doses, it powerfully stimulates LH and FSH release, producing a strong hormonal axis restart. This makes it valuable for post-cycle therapy following anabolic steroid use, or for cases of hypogonadotropic hypogonadism where the HPG axis needs a potent stimulus to resume function. Some protocols use a single low dose to trigger a full axis restart.
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HMG (Human Menopausal Gonadotropin) is a purified preparation containing both FSH (Follicle-Stimulating Hormone) and LH (Luteinizing Hormone) derived from the urine of postmenopausal women. It directly stimulates the ovaries to develop follicles and produce estrogen, making it a cornerstone of fertility treatment and ovulation induction protocols. By providing both FSH and LH, HMG supports the complete follicular development process — from recruitment through maturation and ovulation — making it more comprehensive than FSH-only preparations for many fertility applications.
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Triptorelin Acetate in women's health applications works through the same GnRH receptor mechanism as in men, but is commonly used for different purposes: in fertility protocols, low-dose pulsatile administration stimulates the HPG axis, while in other applications it may be used for temporary hormonal suppression. In ART protocols, it prevents premature LH surges that could compromise egg retrieval timing. In endometriosis management, it creates a temporary hypoestrogenic state that allows endometrial tissue regression. Dosing strategy determines whether stimulation or suppression is achieved.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
GHK-Cu (Copper Peptide GHK-Cu) is a naturally occurring tripeptide-copper complex found in human plasma, saliva, and urine that dramatically declines with age. It exerts broad anti-aging effects by activating over 300 genes involved in tissue remodeling, collagen synthesis, antioxidant defense, and stem cell activation. In skin, it stimulates fibroblasts to produce collagen and elastin, improves skin density and elasticity, reduces fine lines, and accelerates wound healing. In hair, it extends the anagen (growth) phase and reactivates dormant follicles.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
Matrixyl (Palmitoyl Pentapeptide-4) is a lipopeptide consisting of a palmitic acid chain attached to a pentapeptide that signals fibroblasts to produce collagen, elastin, and hyaluronic acid. It mimics the natural peptide signals released when collagen breaks down — essentially tricking the skin into accelerating its repair and rebuilding process. Clinical studies have shown significant reductions in wrinkle depth and improvements in skin smoothness with consistent use. It is one of the most evidence-backed anti-aging peptides available.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
SNAP-8 (Acetyl Octapeptide-3) is an octapeptide that mimics the N-terminal end of SNAP-25 — a protein involved in the release of neurotransmitters at neuromuscular junctions. By competing with SNAP-25, it reduces acetylcholine release at the neuromuscular junction, causing partial relaxation of facial muscles responsible for expression wrinkles. The effect is similar to Botox but topical, reversible, and non-paralytic — producing a smoothing effect on dynamic wrinkles without the frozen appearance or injection risk of neurotoxins.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
Melanotan I (Afamelanotide) is a synthetic analogue of alpha-melanocyte stimulating hormone (α-MSH) that selectively activates MC1R receptors to stimulate melanin production in skin cells. By increasing melanin — the pigment responsible for skin color — it provides both cosmetic tanning effects and genuine photoprotection by absorbing and dissipating UV radiation. It has a more selective receptor profile than Melanotan II, producing strong tanning effects with significantly reduced sexual stimulation side effects. Its analogue Afamelanotide is FDA-approved for erythropoietic protoporphyria.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
Melanotan II is a synthetic cyclic analogue of alpha-MSH that activates multiple melanocortin receptors — MC1R for tanning, MC3R and MC4R for sexual arousal, appetite suppression, and metabolic effects. This broad receptor activation makes it a potent multi-effect compound: producing deep tanning, significant libido enhancement, appetite reduction, and mild fat loss simultaneously. Its non-selective receptor profile is responsible for both its wide range of effects and its more pronounced side effect profile compared to Melanotan I.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
Bronchogen is a tetrapeptide bioregulator derived from bronchial tissue, developed by the St. Petersburg Institute of Bioregulation and Gerontology. Like all bioregulators, it works by binding to specific DNA sequences in bronchial and lung cells to normalize gene expression and restore cellular function that has declined with age or disease. It supports protein synthesis in respiratory epithelium, reduces inflammation in bronchial tissue, and promotes healthy mucociliary function. Bioregulators represent a precision anti-aging approach — each peptide restores function specifically in its target organ.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
Cardiogen is a tetrapeptide bioregulator specifically targeting cardiac muscle (myocardium) cells. It normalizes protein synthesis in cardiomyocytes, supports mitochondrial function in heart tissue, and reduces age-related deterioration of cardiac muscle. Like all bioregulators from the St. Petersburg Institute, it works epigenetically — binding to chromatin in cardiac cells to restore youthful gene expression patterns. It has been studied in clinical settings for supporting cardiac function in elderly patients and those recovering from cardiac events.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
Chonluten is a tripeptide bioregulator (Lys-Glu-Asp) that specifically targets bronchial mucosal cells — the epithelial lining of the airways responsible for mucus production and mucociliary clearance. It normalizes gene expression in bronchial epithelium, restoring proper mucociliary function, reducing pathological inflammation, and supporting healthy airway barrier integrity. While Bronchogen targets deeper lung tissue, Chonluten focuses on the mucosal lining — making them complementary for comprehensive respiratory anti-aging.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
Cortagen is a tetrapeptide bioregulator targeting nervous system cells — both central (brain and spinal cord) and peripheral. It normalizes protein synthesis in neurons, supports myelin sheath integrity, promotes nerve cell regeneration, and reduces neuroinflammation. Age-related neurological decline is driven largely by reduced protein synthesis in neurons and progressive neuroinflammation — both of which Cortagen addresses at the gene expression level. It is particularly valuable for peripheral neuropathy and age-related cognitive decline as part of a comprehensive bioregulator protocol.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
Crystagen is a tripeptide bioregulator targeting connective tissue — specifically cartilage, tendons, and joint-supporting structures. It normalizes protein synthesis in chondrocytes (cartilage cells) and fibroblasts, promotes healthy collagen and proteoglycan production, and reduces inflammatory processes that drive joint degeneration. As part of the Russian bioregulator system, it works epigenetically to restore youthful connective tissue function that has declined with age or injury.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
Humanin is a mitochondria-derived peptide encoded in the 16S rRNA region of the mitochondrial genome. It was originally discovered through its ability to rescue neurons from amyloid beta-induced death, making it one of the most studied peptides in Alzheimer's disease research. It exerts broad cytoprotective effects by activating survival pathways in stressed cells, improving insulin sensitivity, protecting cardiac muscle from ischemia, and reducing neuroinflammation. Humanin levels decline significantly with age and in neurodegenerative disease, making supplementation particularly valuable for longevity-focused protocols.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
Liveagen is a tetrapeptide bioregulator that specifically targets hepatocytes — the primary functional cells of the liver. It normalizes gene expression in liver cells, promotes healthy protein synthesis, supports mitochondrial function in hepatocytes, and reduces age-related fibrotic changes in liver tissue. Given the liver's central role in detoxification, hormone metabolism, and biochemical synthesis, maintaining liver health is foundational to overall health and longevity. Liveagen addresses liver aging at the cellular level as part of a comprehensive bioregulator protocol.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
Pancragen is a tetrapeptide bioregulator targeting pancreatic cells — both exocrine (digestive enzyme production) and endocrine (insulin-producing beta cells). It normalizes protein synthesis in pancreatic tissue, supports beta cell regeneration, and improves insulin secretion capacity. Age-related pancreatic decline is a significant driver of metabolic dysfunction and type 2 diabetes risk. Pancragen addresses this decline at the cellular level, restoring pancreatic function and improving glucose regulation as part of a comprehensive anti-aging metabolic protocol.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
PNC-27 is a synthetic peptide containing a segment of the p53 tumor suppressor protein that binds to MDM-2 (HDM-2 in humans) — a protein overexpressed on the surface of many cancer cells. When PNC-27 binds to MDM-2 on cancer cell membranes, it inserts into and destroys the membrane through a process called membranolysis — causing selective cancer cell death while leaving normal cells unharmed, as normal cells express little to no surface MDM-2. It has been studied against pancreatic, breast, melanoma, leukemia, and other cancer cell lines with significant results.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
Testagen is a tetrapeptide bioregulator targeting testicular cells — specifically Leydig cells responsible for testosterone production. It normalizes gene expression in testicular tissue, promotes healthy steroidogenesis, and restores testosterone production capacity that declines with age. Unlike exogenous testosterone, Testagen works by restoring the testes' own production capability — making it ideal for men wanting to optimize natural testosterone without suppressing their HPG axis. When combined with Gonadorelin or HCG in TRT protocols, it supports comprehensive testicular health.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
Thymogen is a synthetic dipeptide (Glu-Trp) derived from thymic tissue that acts as a potent immunomodulator. Despite its simple structure, it effectively stimulates T-lymphocyte differentiation, increases IL-2 production, enhances NK cell activity, and normalizes the cytokine balance in immune-compromised individuals. It is one of the simplest bioregulator peptides and among the most extensively studied for immune restoration. Thymogen complements Thymalin's broader thymic extract effects with a targeted, minimalist signaling approach.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
Vesugen is a tripeptide bioregulator targeting vascular endothelial cells — the cells lining blood vessel walls. It normalizes gene expression in endothelial tissue, promotes healthy vascular protein synthesis, reduces oxidative damage in blood vessel walls, and supports endothelial function that declines with age and cardiovascular risk factors. Vascular aging — characterized by endothelial dysfunction, reduced elasticity, and increased atherosclerosis risk — is a primary driver of cardiovascular disease and overall aging. Vesugen addresses this at the cellular level as part of a comprehensive cardiovascular anti-aging protocol.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
EPO (Erythropoietin) is a glycoprotein hormone naturally produced by the kidneys that stimulates the bone marrow to produce red blood cells. By increasing red blood cell count and hemoglobin levels, EPO dramatically improves oxygen delivery to muscles — the primary determinant of aerobic endurance capacity. It is the body's natural response to altitude and hypoxic stress, and synthetic EPO replicates this effect to a powerful degree. It has been used clinically for anemia treatment and has gained notoriety in endurance sports for its dramatic performance-enhancing effects.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
Testosterone Cypionate is a long-chain ester of testosterone with a half-life of approximately 8 days, making it ideal for once or twice-weekly injection protocols. It delivers exogenous testosterone that converts to DHT and estradiol as needed, restoring the full spectrum of testosterone's physiological effects — anabolic (muscle building, fat loss), androgenic (libido, energy, mood), and cognitive (focus, motivation, confidence). Cypionate is the most widely prescribed TRT ester in the US due to its convenient dosing schedule and predictable pharmacokinetics.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
Testosterone Enanthate is a long-chain testosterone ester with a half-life of approximately 4–5 days — slightly shorter than Cypionate, but functionally very similar for TRT purposes. It is the most widely used testosterone ester globally and the international standard for TRT outside the United States. The pharmacological effects are identical to Cypionate — full testosterone restoration with anabolic, androgenic, and cognitive benefits. The slight half-life difference means some clients prefer Enanthate for twice-weekly dosing to maintain more stable blood levels.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
Testosterone Propionate is a short-chain testosterone ester with a half-life of approximately 2–3 days, requiring more frequent injections (every other day or every 2 days) but offering greater control over blood levels. Its shorter half-life means faster onset of effects, quicker clearance from the system, and easier dose adjustment if side effects develop. Many clients prefer Propionate for its lower water retention compared to longer esters and its ability to fine-tune testosterone levels with greater precision.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.
Sustanon 250 is a blend of four testosterone esters: Testosterone Propionate (30mg), Testosterone Phenylpropionate (60mg), Testosterone Isocaproate (60mg), and Testosterone Decanoate (100mg). This combination provides both rapid onset (from the short-chain propionate and phenylpropionate) and sustained release (from the longer isocaproate and decanoate esters), creating a pharmacokinetic profile that covers the full testosterone release window with a single injection. It is widely used in European clinical TRT settings and is appreciated for its convenience and comprehensive ester coverage.
Education Only — Not Medical Advice. This overview is for informational purposes only and does not constitute a treatment plan, diagnosis, or prescription. Consult a licensed healthcare provider before beginning any protocol. Coleman & Co. does not diagnose, treat, or prescribe.