Retatrutide Protocol — Coleman & Co.

How to Use This Page

1

Choose Your BAC Volume

Pick 1, 2, or 3 mL of bacteriostatic water. Each column shows the resulting concentration and unit draw for every dose.

2

Find Your Dose

Your prescribed doses are highlighted in blue. The rows above and below show nearby options for reference. Draw the units shown for your dose.

3

Follow the Schedule

Your dosing calendar is below — weeks, dose amounts, and injection days. A check-in is scheduled at week 6 to review progress.

Reconstitution Guide

1 mL

BAC Water

20 mg/mL · 1 mg = 5 units

Dose	Draw
0.5 mg	2.5 units
1.0 mg	5 units
1.5 mg	7.5 units
2.0 mg Jake	10 units
2.5 mg Jake	12.5 units
3.0 mg Jake	15 units
3.5 mg	17.5 units
4.0 mg	20 units
4.5 mg	22.5 units

2 mL

BAC Water

10 mg/mL · 1 mg = 10 units

Dose	Draw
0.5 mg	5 units
1.0 mg	10 units
1.5 mg	15 units
2.0 mg Jake	20 units
2.5 mg Jake	25 units
3.0 mg Jake	30 units
3.5 mg	35 units
4.0 mg	40 units
4.5 mg	45 units

3 mL

BAC Water

6.67 mg/mL · 1 mg = 15 units

Dose	Draw
0.5 mg	7.5 units
1.0 mg	15 units
1.5 mg	22.5 units
2.0 mg Jake	30 units
2.5 mg Jake	37.5 units
3.0 mg Jake	45 units
3.5 mg	52.5 units
4.0 mg	60 units
4.5 mg	67.5 units

Dosing Schedule

Weeks

Dose

Days

Note

1–2

2 mg ×2/wk

Mon · Thu

Starting dose

3–4

2.5 mg ×2/wk

Mon · Thu

Titration

5–12

3 mg ×2/wk

Mon · Thu

Maintenance

📅

Week 6 check-in scheduled. We'll meet to review progress and discuss if further adjustments are needed.

Cycle Supply

Period	Dose × Days	Total
Weeks 1–2	2 mg × 2/wk × 2 wks	8.0 mg
Weeks 3–4	2.5 mg × 2/wk × 2 wks	10.0 mg
Weeks 5–12	3 mg × 2/wk × 8 wks	48.0 mg
Total needed		66.0 mg

4 vials needed (20 mg each) · 66.0 mg ÷ 20 mg = 3.3 → 4 vials

How to Reconstitute

Sanitize vial tops and injection port with an alcohol swab. Let dry.
Draw BAC water into your syringe — use the volume from the guide above (1, 2, or 3 mL).
Inject slowly into the peptide vial, aiming the stream down the side wall — not directly onto the lyophilized puck.
Swirl gently — do not shake. Let it sit 5–10 minutes until fully dissolved. Solution should be clear.
Refrigerate immediately. Use within 28 days of reconstitution.

About Retatrutide

What Is Retatrutide?

Retatrutide is a triple-receptor agonist — it activates three metabolic pathways simultaneously: GLP-1, GIP, and glucagon receptors. This makes it distinct from single-pathway peptides like semaglutide (GLP-1 only) or tirzepatide (GLP-1 + GIP).

🧬

GLP-1

Slows gastric emptying, increases satiety, improves insulin sensitivity

⚡

GIP

Enhances insulin secretion, improves glucose disposal, supports energy partitioning

🔥

Glucagon

Increases energy expenditure, promotes lipolysis (fat burning), supports metabolic rate

Why Triple Agonism Matters

The addition of glucagon receptor activation is what sets retatrutide apart. While GLP-1 and GIP work primarily through appetite suppression and glucose regulation, glucagon signaling directly increases energy expenditure — your body burns more calories at rest. This creates a dual mechanism: you eat less and your metabolism runs hotter.

What to Expect

Appetite changes are typically the first noticeable effect — reduced hunger, earlier fullness, and fewer food cravings. These tend to appear within the first 1–2 weeks. Metabolic effects (increased energy burn) build more gradually over 4–8 weeks as the glucagon pathway upregulates.

Common experiences include mild nausea, changes in bowel habits, and occasional fatigue — especially during the first week after each dose increase. These are dose-dependent and usually resolve as your body adapts. Staying hydrated and eating smaller, more frequent meals helps significantly.

Cycle Duration & Monitoring

This protocol runs 12 weeks with a structured titration: 2 mg → 2.5 mg → 3 mg, each step held for 2 weeks before advancing. A mid-cycle check-in at week 6 allows us to assess response, adjust if needed, and plan the second half of the cycle. After week 12, we'll evaluate whether to continue, titrate up, or begin a washout period.